Delta variant rapidly spread throughout the country with the highest impact on lives and the economy. Myanmar has also faced a rapid-surged third wave which started at the end of May 2021. There were 142,944 confirmed cases (278 per 100,000 population) with 3,210 deaths (6 per 100,000 population) and 2.25% CFR during the second wave. The second wave started in mid-August 2020 in Rakhine State and the disease spread to the whole country. Ministry of Health (MOH) reported that there were 374 confirmed cases (0.73 per 100,000 population) and 6 deaths (0.01 per 100,000 population) with 1.60% case fatality rate (CFR) during the first wave of the epidemic. Incidence of COVID-19 cases and deaths per 100,000 population were expressed in accordance with the total population of the 2014 National Census in Myanmar (51,486,253 persons). The first cases of COVID-19 were reported on 23rd March 2020 and the epidemic started its exponential growth in April 2020. In Myanmar, there were 612,883 confirmed cases of COVID-19, including 19,434 deaths as of 30th April 2022. In the current world, many countries are experiencing different waves of coronavirus disease 2019 (COVID-19) due to the respective dominant variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This communication intends to give insights on what should be considered as the proper mitigation measures to contain the disease spread through the community and as the challenges that occur in implementing public health and social measures. Although decreasing the number of COVID-19 cases and deaths, Myanmar is facing the challenges such as human resource shortages in the health sector, community trust for vaccine safety, and inequitable vaccine demand. Myanmar performed the main community mitigation measures such as strict quarantine for the people who came back from foreign countries, expansion of testing capacity, enforcement of non-pharmaceutical interventions, and improvement of COVID-19 vaccination coverage. Omicron had already become a dominant variant in Myanmar and then, the fourth wave of the COVID-19 epidemic started on 28th January 2022. Many countries performed mitigation measures to contain the disease spread and break the exponential curve. The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 has affected day-to-day life worldwide and presents an unprecedented challenge to public health.
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